Induced chronic intravascular coagulation in dogs.

When an emulsion of dog brain thromboplastin was infused continuously into dogs for 1--4 weeks only platelets and factor XI were consistently depressed. The remaining clotting factors fell in a dose-dependent fashion but there was a tendency toward recovery despite continued infusion of thromboplastin. Fibrinogen and factor V were unique in that with weaker emulsions of thromboplastin, they often rose without a preliminary fall.