Nature clinical practice. Endocrinology & metabolism · 2008
Treatment of male infertility secondary to morbid obesity.
Клинический случайСтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Roth Mara Y, Amory John K, Page Stephanie T
Аннотация
BACKGROUND: A 29-year-old man presented to a clinic with infertility and hypogonadism in the setting of morbid obesity. On presentation, he had notable gynecomastia and a low testicular volume. The patient's weight was 154 kg and his height was 168 cm (BMI 54.5 kg/m(2)). Before referral to the clinic, the patient had been treated with testosterone therapy for 4 months for hypogonadism. This treatment had caused his initially low sperm concentration to fall to undetectable levels.
INVESTIGATIONS: Measurement of reproductive hormone levels, pituitary MRI, and semen analysis.
DIAGNOSIS: Infertility secondary to hypogonadotropic hypogonadism and an elevated estrogen:testosterone ratio.
MANAGEMENT: Treatment with an aromatase inhibitor, anastrozole, led to normalization of the patient's testosterone, luteinizing hormone and follicle-stimulating hormone levels, suppression of serum estradiol levels, and to normalization of spermatogenesis and fertility.
INVESTIGATIONS: Measurement of reproductive hormone levels, pituitary MRI, and semen analysis.
DIAGNOSIS: Infertility secondary to hypogonadotropic hypogonadism and an elevated estrogen:testosterone ratio.
MANAGEMENT: Treatment with an aromatase inhibitor, anastrozole, led to normalization of the patient's testosterone, luteinizing hormone and follicle-stimulating hormone levels, suppression of serum estradiol levels, and to normalization of spermatogenesis and fertility.