A multicenter analysis of inpatient antibiotic use during the 2015-2019 influenza seasons in the United States: Untapped opportunities for antimicrobial stewardship.

Outpatient antibiotic use increases during winter months, but information on temporal changes in inpatient antibiotic use in US hospitals is limited. The use of certain inpatient antibiotics, including extended-spectrum cephalosporins, macrolides, and tetracyclines, was strongly associated with influenza activity during the 2015-2019 viral respiratory seasons.