Fertility and sterility · 2013
Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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de Mendonça-Louzeiro Maria Raquel Marques Furtado, Annichino-Bizzacchi Joyce Maria, Magna Luís Alberto, Quaino Susan Kelly Picoli, Benetti-Pinto Cristina Laguna
Аннотация
OBJECTIVE: To evaluate hemostatic markers in women with polycystic ovary syndrome (PCOS) compared with healthy controls matched for age and body mass index.
DESIGN: Cross-sectional study.
SETTING: Tertiary teaching hospital.
PATIENT(S): Forty-five women with PCOS and 45 controls paired for age (±2 years) and body mass index (±2 kg/m(2)).
INTERVENTION(S): Clinical evaluation and venipuncture.
MAIN OUTCOME MEASURE(S): Thrombin activatable fibrinolysis inhibitor, D-dimer, plasminogen activator inhibitor-1, and the thrombin generation test.
RESULT(S): Thrombin generation lag-time was significantly shorter in women with PCOS compared with controls. The other hemostatic parameters were similar in both groups.
CONCLUSION(S): Thrombin generation is faster in young and overweight women with PCOS, suggesting a greater risk of hypercoagulability.
DESIGN: Cross-sectional study.
SETTING: Tertiary teaching hospital.
PATIENT(S): Forty-five women with PCOS and 45 controls paired for age (±2 years) and body mass index (±2 kg/m(2)).
INTERVENTION(S): Clinical evaluation and venipuncture.
MAIN OUTCOME MEASURE(S): Thrombin activatable fibrinolysis inhibitor, D-dimer, plasminogen activator inhibitor-1, and the thrombin generation test.
RESULT(S): Thrombin generation lag-time was significantly shorter in women with PCOS compared with controls. The other hemostatic parameters were similar in both groups.
CONCLUSION(S): Thrombin generation is faster in young and overweight women with PCOS, suggesting a greater risk of hypercoagulability.