Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index.

OBJECTIVE

To evaluate hemostatic markers in women with polycystic ovary syndrome (PCOS) compared with healthy controls matched for age and body mass index.

DESIGN

Cross-sectional study.

SETTING

Tertiary teaching hospital.

PATIENT(S): Forty-five women with PCOS and 45 controls paired for age (±2 years) and body mass index (±2 kg/m(2)).

INTERVENTION(S): Clinical evaluation and venipuncture.

MAIN OUTCOME MEASURE(S): Thrombin activatable fibrinolysis inhibitor, D-dimer, plasminogen activator inhibitor-1, and the thrombin generation test.

RESULT(S): Thrombin generation lag-time was significantly shorter in women with PCOS compared with controls. The other hemostatic parameters were similar in both groups.

CONCLUSION(S): Thrombin generation is faster in young and overweight women with PCOS, suggesting a greater risk of hypercoagulability.