Voprosy pitaniia · 2026
[New possibilities for dietary correction of body weight and lipid metabolism in patients with obesity].
СтатьяНаблюдательное исследованиеАннотация на английскомНазвание и аннотация: Перевод в очереди
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Pilat T L, Kuzmina L P, Khotuleva A G, Kolyaskina M M
Аннотация
UNLABELLED: Overweight, obesity, and dyslipidemia significantly contribute to the development of atherosclerotic cardiovascular disease. Among non-drug treatments, dietary therapy using foods for special dietary uses is the most effective. The purpose of the study was to evaluate the possibilities of dietary correction of body weight and lipid metabolism in patients with overweight and obesity using the "Weight and Cholesterol Reduction" (WCR) nutrition program.
MATERIAL AND METHODS: An observational cohort study was conducted involving 20 women aged 25 to 50 years with initially high total serum cholesterol (>6.2 mmol/L) and a body mass index (BMI) over 25.0 kg/m2. The effectiveness of the WCR nutrition program was assessed based on changes in anthropometric parameters, blood lipid profile [total cholesterol, triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) level], fasting blood glucose level, and changes in liver function (the activity of organ-specific liver enzymes and level of total and direct bilirubin). The organoleptic properties and tolerability of the WCR program products were assessed using a questionnaire.
RESULTS: After two weeks of using the WCR nutrition program, the body weight of the subjects decreased to 4.7 kg (from 82.4±5.7 to 77.7±5.4 kg), blood serum level of total cholesterol decreased by 12% (from 7.12±0.43 to 6.26±0.36 mmol/L), triglycerides - by 17% (from 2.18±0.45 to 1.81±0.38 mmol/L), LDL - by 8.7% (from 4.42±0.38 to 4.03±0.35 mmol/L) (p<0.05), which is justified by a decrease in the diet calorie intake and fat consumption, the exclusion of cholesterol-rich foods from the diet, and the inclusion of pectin, chlorogenic acid and β-glucans in the diet, which contribute to lipid profile improvement. Enhancing liver function was noted: the activity of alanine and aspartate aminotransferase decreased (p>0.05) by 14.2% (from 48.2±17.1 to 41.4±14.2 U/L) and 7.7% (from 41.6±12.9 to 38.4±11.5 U/l), respectively, the bilirubin level decreased [total by 16% (from 14.2±3.6 to 11.9±3.1 μmol/L), direct by 17.4% (from 3.9±1.2 to 3.2±1.0 μmol/L)]. Improvement in carbohydrate metabolism was revealed: the blood glucose level decreased by 9.5% (from 5.95±0.42 to 5.38±0.38 U/l) (p<0.05).
CONCLUSION: The WCR nutrition program can serve as an effective mean for weight loss and normalization of lipid and carbohydrate metabolism in individuals with obesity and hyperlipidemia.
MATERIAL AND METHODS: An observational cohort study was conducted involving 20 women aged 25 to 50 years with initially high total serum cholesterol (>6.2 mmol/L) and a body mass index (BMI) over 25.0 kg/m2. The effectiveness of the WCR nutrition program was assessed based on changes in anthropometric parameters, blood lipid profile [total cholesterol, triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) level], fasting blood glucose level, and changes in liver function (the activity of organ-specific liver enzymes and level of total and direct bilirubin). The organoleptic properties and tolerability of the WCR program products were assessed using a questionnaire.
RESULTS: After two weeks of using the WCR nutrition program, the body weight of the subjects decreased to 4.7 kg (from 82.4±5.7 to 77.7±5.4 kg), blood serum level of total cholesterol decreased by 12% (from 7.12±0.43 to 6.26±0.36 mmol/L), triglycerides - by 17% (from 2.18±0.45 to 1.81±0.38 mmol/L), LDL - by 8.7% (from 4.42±0.38 to 4.03±0.35 mmol/L) (p<0.05), which is justified by a decrease in the diet calorie intake and fat consumption, the exclusion of cholesterol-rich foods from the diet, and the inclusion of pectin, chlorogenic acid and β-glucans in the diet, which contribute to lipid profile improvement. Enhancing liver function was noted: the activity of alanine and aspartate aminotransferase decreased (p>0.05) by 14.2% (from 48.2±17.1 to 41.4±14.2 U/L) and 7.7% (from 41.6±12.9 to 38.4±11.5 U/l), respectively, the bilirubin level decreased [total by 16% (from 14.2±3.6 to 11.9±3.1 μmol/L), direct by 17.4% (from 3.9±1.2 to 3.2±1.0 μmol/L)]. Improvement in carbohydrate metabolism was revealed: the blood glucose level decreased by 9.5% (from 5.95±0.42 to 5.38±0.38 U/l) (p<0.05).
CONCLUSION: The WCR nutrition program can serve as an effective mean for weight loss and normalization of lipid and carbohydrate metabolism in individuals with obesity and hyperlipidemia.