Journal of magnetic resonance imaging : JMRI · 2016
Breathing maneuvers as a coronary vasodilator for myocardial perfusion imaging.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Teixeira Tiago, Nadeshalingam Gobinath, Fischer Kady, Marcotte François, Friedrich Matthias G
Аннотация
PURPOSE: A combined breathing maneuver of hyperventilation, followed by a long voluntary breathhold leads to coronary vasodilation. We investigated the impact of breathing maneuvers on MR first-pass cardiac perfusion imaging and its potential clinical utility.
MATERIALS AND METHODS: We studied 24 healthy volunteers (37 ± 12 years; 62.5% men) on a clinical 3 Tesla MRI system and performed first-pass perfusion MR at rest, during a short breathhold (S-HVBH) following 60 s of hyperventilation, and at the end of a long breathhold (L-HVBH) following the hyperventilation, performed in random order. A blinded reader analyzed signal intensity upslope, upslope index, and time between 20 and 80% of maximal signal.
RESULTS: All volunteers tolerated the breathing maneuvers well and completed the study protocol. The upslope of the signal-intensity-over-time curve was increased during S-HVBH (1.86 ± 0.70 units/s, P < 0.05) and at the end of L-LVBH (1.77 ± 0.82 units/s), when compared with baseline results (1.34 ± 0.58 units/s). Corrected for the arterial input, the upslope was higher at the end of the L-HVBH (0.095 ± 0.019 units/s versus 0.077 ± 0.016 units/s at rest, P < 0.01) as was the myocardial perfusion reserve index (1.25 ± 0.22 versus 1.09 ± 0.17; P < 0.001). In a multiple regression model, only gender, rate-pressure product, and breathhold time were independently and significantly related to the upslope (R = 0.771; P < 0.001).
CONCLUSION: In conclusion, a voluntary long breathhold after hyperventilation leads to an increase of the myocardial perfusion reserve index. This may impact findings from current practice of first-pass perfusion imaging. The clinical utility of breathing maneuvers as a vasodilatory stimulus for first-pass perfusion imaging may warrant further research. J. MAGN. RESON. IMAGING 2016;44:947-955.
MATERIALS AND METHODS: We studied 24 healthy volunteers (37 ± 12 years; 62.5% men) on a clinical 3 Tesla MRI system and performed first-pass perfusion MR at rest, during a short breathhold (S-HVBH) following 60 s of hyperventilation, and at the end of a long breathhold (L-HVBH) following the hyperventilation, performed in random order. A blinded reader analyzed signal intensity upslope, upslope index, and time between 20 and 80% of maximal signal.
RESULTS: All volunteers tolerated the breathing maneuvers well and completed the study protocol. The upslope of the signal-intensity-over-time curve was increased during S-HVBH (1.86 ± 0.70 units/s, P < 0.05) and at the end of L-LVBH (1.77 ± 0.82 units/s), when compared with baseline results (1.34 ± 0.58 units/s). Corrected for the arterial input, the upslope was higher at the end of the L-HVBH (0.095 ± 0.019 units/s versus 0.077 ± 0.016 units/s at rest, P < 0.01) as was the myocardial perfusion reserve index (1.25 ± 0.22 versus 1.09 ± 0.17; P < 0.001). In a multiple regression model, only gender, rate-pressure product, and breathhold time were independently and significantly related to the upslope (R = 0.771; P < 0.001).
CONCLUSION: In conclusion, a voluntary long breathhold after hyperventilation leads to an increase of the myocardial perfusion reserve index. This may impact findings from current practice of first-pass perfusion imaging. The clinical utility of breathing maneuvers as a vasodilatory stimulus for first-pass perfusion imaging may warrant further research. J. MAGN. RESON. IMAGING 2016;44:947-955.