Medicinal Potential of Broussonetia papyrifera: Chemical Composition and Biological Activity Analysis.

Broussonetia papyrifera (L.) L'Hér. ex Vent., a dioecious tree species that belongs to the Moraceae family, is a perennial plant found extensively throughout China. Its leaves are rich in essential trace elements such as copper, molybdenum, manganese, and iron, as well as various biologically active compounds, including amino acids, polysaccharides, proteins, as well as flavonoids, phenylpropanoids, and other polyphenolic compounds. These compounds exhibit significant pharmacological effects, such as antioxidant, lipid-lowering, heat-clearing, detoxifying, blood-cooling, diuretic, and immunomodulatory activities. In recent years, B. papyrifera has gained attention for its medicinal potential; however, breeding efforts, especially those aimed at increasing the flavonoid content, have lagged. This study reviews the progress in research on the active medicinal ingredients of B. papyrifera, with a focus on identification methods, classification criteria, and enrichment technologies for its medicinal components. The biosynthesis of structural genes and transcription factors in flavonoids has been investigated in B. papyrifera. The pharmacological effects of the secondary metabolites of B. papyrifera were systematically examined, aiming to offer strategies for enhancing the flavonoid content and promoting its medicinal value.