Perigraft inflammation due to Dacron-covered stent-grafts in sheep iliac arteries: correlation of MR imaging and histopathologic findings.

PURPOSE: To evaluate with magnetic resonance (MR) imaging the inflammatory perigraft response after implantation of Dacron-covered and noncovered arterial endovascular prostheses in sheep.

MATERIALS AND

METHODS

Four prosthesis types--two Dacron-covered nitinol stent-grafts (plain and heparin-coated) and two noncovered nitinol stents (Memotherm and Cragg)--were each inserted into the external iliac arteries of eight sheep. MR imaging before and after gadolinium enhancement was performed 5-8 days and 1 month after implantation (before the animals were killed). Macroscopic and microscopic examinations of the vessels were performed, and findings were correlated with those on MR images.

RESULTS

Severe inflammatory perigraft responses to the heparin-coated Dacron-covered stent-grafts were found; MR images demonstrated contrast enhancement and edema. Macroscopic examination showed marked vascular wall thickening and adhesions around the Dacron fabric; microscopic examination showed a pronounced inflammatory foreign-body response. There was a moderate inflammatory response to the plain Dacron-covered stent-grafts and almost no response to noncovered stents.

CONCLUSION

In sheep, MR imaging findings of perigraft soft-tissue edema and contrast enhancement correlated well with histopathologic findings of severe perigraft inflammation due to heparin-coated Dacron-covered stent-grafts.