Folia neuropathologica · 2026
Neuroectodermal interleukin 12 signaling attenuates spinal cord inflammation and demyelination.
СтатьяНазвание и аннотация: Перевод в очереди
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Mehmood Arshad, Din Miraj, Munawer Muhammad, Shah Sunil, Liu Xiaohui, Jiang Hui, Wang Xuemei
Аннотация
INTRODUCTION: Interleukin 12 (IL-12) is a driver of type 1 immunity. Interleukin 12 reduces inflammation in an autoimmune condition in the spinal cord. The aim of this study was to investigate the therapeutic effect of IL-12 in the experimental autoimmune encephalomyelitis model.
MATERIAL AND METHODS: Interleukin 12 expression was mapped in neurons, oligodendrocytes, natural killer cells, and T lymphocyte cells in the spinal cord of experimental autoimmune encephalomyelitis mice.
RESULTS: Interleukin 12 ablation in neurons, oligodendrocytes, natural killer, and T lymphocyte cells in mice and their susceptibility to experimental autoimmune encephalomyelitis showed that the neuroprotective role of IL-12 is mediated by neuroectoderm-derived cells - neurons.
CONCLUSIONS: Single-nucleus RNA sequencing revealed an IL-12 receptor-induced neuroprotective effect that prevents neurodegeneration, sustains trophic factor release in neuroinflammation, and maintains spinal cord integrity.
MATERIAL AND METHODS: Interleukin 12 expression was mapped in neurons, oligodendrocytes, natural killer cells, and T lymphocyte cells in the spinal cord of experimental autoimmune encephalomyelitis mice.
RESULTS: Interleukin 12 ablation in neurons, oligodendrocytes, natural killer, and T lymphocyte cells in mice and their susceptibility to experimental autoimmune encephalomyelitis showed that the neuroprotective role of IL-12 is mediated by neuroectoderm-derived cells - neurons.
CONCLUSIONS: Single-nucleus RNA sequencing revealed an IL-12 receptor-induced neuroprotective effect that prevents neurodegeneration, sustains trophic factor release in neuroinflammation, and maintains spinal cord integrity.