Consensus of the Brazilian Headache Society (SBCe) for prophylactic treatment of episodic migraine: part II.
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Santos Paulo Sergio Faro, Melhado Eliana Meire, Kaup Alexandre Ottoni, Costa Aline Turbino Neves Martins da, Roesler Célia Aparecida de Paula, Piovesan Élcio Juliato, Sarmento Elder Machado, Theotonio Giselle Oliveira Martins, Campos Henrique Carneiro de, Fortini Ida, Souza Jano Alves de, Júnior Jayme Antunes Maciel, Segundo João Batista Alves, Carvalho João José Freitas de, Speziali José Geraldo, Calia Leandro Cortoni, Barea Liselotte Menke, Queiroz Luiz Paulo, Souza Marcio Nattan Portes, Figueiredo Marcos Ravi Cerqueira Ferreira, Costa Maria Eduarda Nobre de Magalhães, Peres Mário Fernando Prieto, Jurno Mauro Eduardo, Peixoto Patrícia Machado, Kowacs Pedro André, Rocha-Filho Pedro Augusto Sampaio, Filho Pedro Ferreira Moreira, Silva-Neto Raimundo Pereira, Fragoso Yara Dadalti
Аннотация
OBJECTIVE: The need to disseminate knowledge about the prophylactic treatment of migraine is known, so the Brazilian Headache Society (SBCe, in the Portuguese acronym) appointed a committee of authors with the objective of establishing a consensus with recommendations on the prophylactic treatment of episodic migraine based on articles from the world literature as well as from personal experience.
METHODS: Meetings were held entirely online, with the participation of 12 groups that reviewed and wrote about the pharmacological categories of drugs and, at the end, met to read and finish the document. The drug classes studied in part II of this Consensus were: antihypertensives, selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, calcium channel blockers, other drugs, and rational polytherapy.
RESULTS: From this list of drugs, only candesartan has been established as effective in controlling episodic migraine. Flunarizine, venlafaxine, duloxetine, and pizotifen were defined as likely to be effective, while lisinopril, enalapril, escitalopram, fluvoxamine, quetiapine, atorvastatin, simvastatin, cyproheptadine, and melatonin were possibly effective in prophylaxis of the disease.
CONCLUSIONS: Despite an effort by the scientific community to find really effective drugs in the treatment of migraine, given the large number of drugs tested for this purpose, we still have few therapeutic options.