Archives of physical medicine and rehabilitation · 2026
Feasibility and Validity of a Remotely Administered 30-Second Sit-to-Stand in People with Multiple Sclerosis.
СтатьяНаблюдательное исследованиеВалидационное исследованиеНазвание и аннотация: Перевод в очереди
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Najafi Parisa, Declerck Louise, Huynh Trinh L T, Jeng Brenda, Motl Robert W
Аннотация
OBJECTIVES: To evaluate the feasibility and validity of the remotely administered 30-second Sit-to-Stand (30s STS) test as a measure of lower-extremity function in a convenience sample of people with multiple sclerosis (MS).
DESIGN: Cross-sectional observational study.
SETTING: Remote, videoconference-based assessments conducted via Zoom.
PARTICIPANTS: Convenience sample of adults with MS (n=541) and healthy controls (n=74).
INTERVENTIONS: Not applicable.
MAIN OUTCOME MEASURES: Number of 30s STS repetitions, completion rate, and correlations of 30s STS performance with cognitive and patient-reported outcome measures.
RESULTS: The remote 30s STS test was completed by 498 participants with MS (92%) and all 74 healthy controls (100%) with no adverse events. The 30s STS performance was significantly lower in the MS than in healthy controls (10.4 vs 14.0 repetitions; P<.001; d=-0.75), and this group difference remained significant after adjusting for group differences in age, sex, and marital status. The 30s STS repetitions were strongly associated with mobility disability (patient-determined disease step: r=-0.56) and walking limitations (12-Item Multiple Sclerosis Walking Scale: r=-0.57); moderately associated with physical health (12-Item Short Form Health Survey Physical Component Summary: r=0.41) and processing speed (Symbol Digit Modalities Test: r=0.34); and weakly associated with symptoms, mental status, verbal learning and memory (California Verbal Learning Test-Second Edition), and physical activity in MS.
CONCLUSIONS: The remotely administered 30s STS appears to be a feasible and valid measure of lower-extremity physical function in stable, relapse-free individuals with MS and may be a useful outcome for telerehabilitation research in this population.
DESIGN: Cross-sectional observational study.
SETTING: Remote, videoconference-based assessments conducted via Zoom.
PARTICIPANTS: Convenience sample of adults with MS (n=541) and healthy controls (n=74).
INTERVENTIONS: Not applicable.
MAIN OUTCOME MEASURES: Number of 30s STS repetitions, completion rate, and correlations of 30s STS performance with cognitive and patient-reported outcome measures.
RESULTS: The remote 30s STS test was completed by 498 participants with MS (92%) and all 74 healthy controls (100%) with no adverse events. The 30s STS performance was significantly lower in the MS than in healthy controls (10.4 vs 14.0 repetitions; P<.001; d=-0.75), and this group difference remained significant after adjusting for group differences in age, sex, and marital status. The 30s STS repetitions were strongly associated with mobility disability (patient-determined disease step: r=-0.56) and walking limitations (12-Item Multiple Sclerosis Walking Scale: r=-0.57); moderately associated with physical health (12-Item Short Form Health Survey Physical Component Summary: r=0.41) and processing speed (Symbol Digit Modalities Test: r=0.34); and weakly associated with symptoms, mental status, verbal learning and memory (California Verbal Learning Test-Second Edition), and physical activity in MS.
CONCLUSIONS: The remotely administered 30s STS appears to be a feasible and valid measure of lower-extremity physical function in stable, relapse-free individuals with MS and may be a useful outcome for telerehabilitation research in this population.