[Interaction of carbon disulfide (CS2 with ethanol in the microsomal monooxygenase system, and its biological consequences].

The interaction of CS2 and ethanol with microsomal monooxygenase and its biological consequences were studied in experimental model on rats exposed concurrently to CS2 (conc. 0,4-1,5 g/m3) and ethanol (10% water solution as the only drink) for 6 months. Prolonged treatment of rats with ethanol resulted in: stimulation of the activity of microsomal monooxygenases microsomal ethanol oxidizing system, increase of the cyt. P-450 level, intensification of lipid peroxidation as well as proliferation of smooth and degranulation of rough endoplasmic reticulum. Combined exposure of rats to CS2 and ethanol resulted in a significant potentation of the depressive effect of CS2 on cyt. P-450 dependent monooxygenases. The alterations induced by CS2, ethanol and both agents in the microsomal monooxygenases are consistent with the observed lipoproteins response.