Clinical endocrinology · 2026
Patients With Pituitary Neuroendocrine Tumours Requiring Neurosurgery -Who Is Referring Them?
СтатьяНазвание и аннотация: Перевод в очереди
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Ahmed Doua S, Herron Brian, Cooke Stephen, Weir Philip, Evanson Jane, Healy Estelle G, Mullan Karen R, Craig Stephanie G, James Jacqueline A, Korbonits Márta, Hunter Steven J, Loughrey Paul Benjamin
Аннотация
OBJECTIVE: Patients living with pituitary neuroendocrine tumours (PitNETs) present with a spectrum of clinical manifestations and often follow a circuitous route to diagnosis, resulting in diagnostic delays. The objective of this study is to identify and report the various sources of referrals for patients who underwent pituitary resection for PitNETs in a tertiary referral centre for pituitary disease.
DESIGN: Retrospective population-based cohort study.
PATIENTS: Patients undergoing a first surgery for management of PitNET in Northern Ireland between 01/01/2000-19/07/2019.
MEASUREMENTS: Demographics, referral sources, incidentaloma rates, apoplexy rates, symptoms, age at diagnosis and diagnostic delay according to referral source.
RESULTS: Data were retrospectively analysed for 520 patients in whom the referral source leading to diagnosis was known. Fifty-seven percent of patients were male. Median age at diagnosis was 54 years (range 18-85). Patients were referred from 29 different sources. The majority of referrals came from general practice (23%), ophthalmology (14%), emergency medicine (9%), optician/optometry (9%) and internists (8%). Twenty-nine patients were referred following radiological discovery of an incidentaloma. Twenty-seven patients were referred with an initial presentation of pituitary apoplexy, with emergency medicine accounting for 70% of these referrals. Visual disturbance and headache were the most frequently documented symptoms. Median diagnostic delay was 2 years (range 0-25 years).
CONCLUSIONS: Patients with PitNETs encounter a range of clinical services in their journey to pituitary surgery. Raising awareness of these tumours and educating healthcare professionals across all disciplines could reduce diagnostic delays, thereby minimising the adverse sequelae of delayed diagnosis.
DESIGN: Retrospective population-based cohort study.
PATIENTS: Patients undergoing a first surgery for management of PitNET in Northern Ireland between 01/01/2000-19/07/2019.
MEASUREMENTS: Demographics, referral sources, incidentaloma rates, apoplexy rates, symptoms, age at diagnosis and diagnostic delay according to referral source.
RESULTS: Data were retrospectively analysed for 520 patients in whom the referral source leading to diagnosis was known. Fifty-seven percent of patients were male. Median age at diagnosis was 54 years (range 18-85). Patients were referred from 29 different sources. The majority of referrals came from general practice (23%), ophthalmology (14%), emergency medicine (9%), optician/optometry (9%) and internists (8%). Twenty-nine patients were referred following radiological discovery of an incidentaloma. Twenty-seven patients were referred with an initial presentation of pituitary apoplexy, with emergency medicine accounting for 70% of these referrals. Visual disturbance and headache were the most frequently documented symptoms. Median diagnostic delay was 2 years (range 0-25 years).
CONCLUSIONS: Patients with PitNETs encounter a range of clinical services in their journey to pituitary surgery. Raising awareness of these tumours and educating healthcare professionals across all disciplines could reduce diagnostic delays, thereby minimising the adverse sequelae of delayed diagnosis.