Urethritis. Diagnosis of nongonococcal urethritis.

Nongonococcal urethritis (NGU) frequently occurs in men after infection of the lower genital tract with a genital pathogen and is mostly associate with complaint of a scanty, thin discharge and urinary symptoms. Management of NGU includes clinical examination, microbiological diagnosis of genital pathogens, and efficient treatment as well as contact tracing. Diagnosis, especially of the Chlamydia trachomatis, the most frequent cause of NGU, has improved by using amplification assays for the detection of DNA or rRNA. These new methods have the advantage of a higher sensitivity especially for specimens with a low number of infectious agents. In addition, they enable the use of urine as a noninvasive specimen type.