The preparation of MnO2/BSA/CdTe quantum dots complex for ratiometric fluorescence/ T1-weighted MRI detection of H2O2.

Hydrogen peroxide, as the second messenger in cells, plays an essential regulatory role in cell proliferation, differentiation and migration. How to effectively identify H2O2 signals, and detect H2O2 in circulating tumor cells, are essential for the early diagnosis of tumors. Herein a fluorescence and T1-weighted MR dual-mode imaging material, named MnBQ, has been successfully prepared and characterized. Based on the chemical redox reaction between MnBQ and H2O2, a fluorescence/T1-weighted MRI dual-mode sensor has been developed for quantitative analysis of H2O2, of which the lowest limit detection obtained from fluorescence and MRI could reach 2.841 μmol/L and 43.85 μmol/L, respectively. This imaging sensor has dual advantages of high sensitivity and high spatial resolution, which could be a good candidate for monitoring of H2O2 in vivo.