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Войти в исследования Fa yi xue za zhi · 2005
[Lethal anaphylactic shock model induced by human mixed serum in guinea pigs].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ren Guang-Mu, Bai Ji-Wei, Gao Cai-Rong
Аннотация
OBJECTIVE: To establish an anaphylactic shock model induced by human mixed serum in guinea pigs.
METHODS: Eighteen guinea pigs were divided into two groups: sensitized and control, The sensitized group were immunized intracutaneously with human mixed serum and then induced by endocardiac injection after 3 weeks.
RESULTS: Symptoms of anaphylactic shock appeared in the sensitized group. The level of serum IgE were increased in the sensitized group significantly.
CONCLUSIONS: An animal model of anaphylactic shock wer established successfully. It provide a tool for both forensic study and anaphylactic shock therapy.
METHODS: Eighteen guinea pigs were divided into two groups: sensitized and control, The sensitized group were immunized intracutaneously with human mixed serum and then induced by endocardiac injection after 3 weeks.
RESULTS: Symptoms of anaphylactic shock appeared in the sensitized group. The level of serum IgE were increased in the sensitized group significantly.
CONCLUSIONS: An animal model of anaphylactic shock wer established successfully. It provide a tool for both forensic study and anaphylactic shock therapy.