Cytogenetic findings in two cases of carcinoma in situ of the cervix uterus.

Karyotypic analysis of two cases of carcinoma in situ of the cervix uterus, studied on direct preparations by G-banding, revealed numerical and structural abnormalities characteristic of invasive cancers. Abnormalities of chromosome No. 1 were present in both cases. The chromosome No. 1 changes involved isochromosome formation of the long arm (i(1q)) in one case and monosomy in the other. The other chromosomes showing structural aberrations were Nos. 8, 11, and 21. One case revealed the presence of double minute chromatin bodies. The prognosis in both cases was good following excision of the tumor.