Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
Association between total corticosteroid dose and reduced fast-twitch rectus femoris muscle fibers after hematopoietic stem cell transplantation.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Nishikado Nobuyoshi, Wakasugi Tatsushi, Kaida Katsuji, Umeji Atsushi, Sota Koichiro, Takemura Daiki, Sugano Kyohei, Eimoto Kazuki, Sasanuma Naoki, Yoshihara Kyoko, Yoshihara Satoshi, Uchiyama Yuki, Domen Kazuhisa
Аннотация
PURPOSE: Hematopoietic stem cell transplantation (HSCT) is a curative treatment for hematologic diseases. However, corticosteroids used to manage graft-versus-host disease can induce muscle weakness, particularly affecting fast-twitch fibers. The objective of this study was to examine the association between the total corticosteroid dose and the decline in fast-twitch muscle fibers, estimated using surface electromyography (sEMG), as well as to evaluate its impact on muscle strength and physical performance.
METHODS: This prospective observational study included 53 adult patients from a single center in Japan. sEMG of the rectus femoris was performed before and after HSCT to calculate the median frequency (MF), a noninvasive marker of fast-twitch fiber proportion. Additional physical function assessments included isometric knee and hip flexion strength, handgrip strength, body weight, thigh circumference, 30-s chair stand test, and maximum walking speed. Correlations between total corticosteroid dose and changes in each variable were analyzed.
RESULTS: Forty-two patients completed both the pre- and post-HSCT assessments. MF, muscle strength, body weight, thigh circumference, 30-s chair stand test performance, and maximum walking speed exhibited significant reductions (all p < 0.01). The total corticosteroid dose negatively correlated with changes in MF (rs = -0.32), hip flexion strength (rs = -0.43), thigh circumference (rs = -0.32 to -0.40), and 30-s chair stand test performance (rs = -0.45).
CONCLUSIONS: A higher total corticosteroid dose after HSCT may lead to a reduced proportion of fast-twitch fibers, which could be associated with impairments in muscle strength and function.
METHODS: This prospective observational study included 53 adult patients from a single center in Japan. sEMG of the rectus femoris was performed before and after HSCT to calculate the median frequency (MF), a noninvasive marker of fast-twitch fiber proportion. Additional physical function assessments included isometric knee and hip flexion strength, handgrip strength, body weight, thigh circumference, 30-s chair stand test, and maximum walking speed. Correlations between total corticosteroid dose and changes in each variable were analyzed.
RESULTS: Forty-two patients completed both the pre- and post-HSCT assessments. MF, muscle strength, body weight, thigh circumference, 30-s chair stand test performance, and maximum walking speed exhibited significant reductions (all p < 0.01). The total corticosteroid dose negatively correlated with changes in MF (rs = -0.32), hip flexion strength (rs = -0.43), thigh circumference (rs = -0.32 to -0.40), and 30-s chair stand test performance (rs = -0.45).
CONCLUSIONS: A higher total corticosteroid dose after HSCT may lead to a reduced proportion of fast-twitch fibers, which could be associated with impairments in muscle strength and function.