BJU international · 2025
Staging metastatic urothelial cancer with Nectin-4 imaging using Gallium-68-N188 PET/CT.
СтатьяНазвание и аннотация: Перевод в очереди
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Miederer Matthias, Pretze Marc, Abbate Elena, Hartig Andreas, do Mar Ferreira Machado Joana, Böhm Katharina, Sommer Ulrich, Hoberück Sebastian, Bundschuh Ralph A, Kotzerke Jörg, Thomas Christian
Аннотация
OBJECTIVE: To quantify Nectin-4 expression in tumour lesions using the Nectin-4-binding peptide Gallium-68-N188 and positron emission tomography (PET)/computed tomography (CT) in patients with advanced or metastasised urothelial cancer eligible for therapy with the Nectin-4-directed antibody-drug conjugate enfortumab vedotin, in combination with checkpoint inhibitor pembrolizumab (Ev/P).
METHODS: In 10 patients, Nectin-4 PET/CT imaging was analysed before planned systemic therapy with Ev/P based on standardised uptake value (SUV) measurements and the results were correlated to available microscopic findings on Nectin-4 immunohistochemistry and to clinical follow-up.
RESULTS: Nectin-4 PET is suitable for detecting Nectin-4 expression in tumour lesions and demonstrates heterogeneity in Nectin-4 expression - for example, between lymph node metastases and organ metastases. PET imaging of Nectin-4 expression is therefore a potentially clinically relevant method for managing the application of Nectin-4-targeted therapies.
CONCLUSIONS: We show, as a proof of principle, that Nectin-4 expression can be detected on imaging and serves as an innovative biomarker for targeted therapy in urothelial cancer. Intra-individual heterogeneous expression of Nectin-4 in metastatic sites is frequent.
METHODS: In 10 patients, Nectin-4 PET/CT imaging was analysed before planned systemic therapy with Ev/P based on standardised uptake value (SUV) measurements and the results were correlated to available microscopic findings on Nectin-4 immunohistochemistry and to clinical follow-up.
RESULTS: Nectin-4 PET is suitable for detecting Nectin-4 expression in tumour lesions and demonstrates heterogeneity in Nectin-4 expression - for example, between lymph node metastases and organ metastases. PET imaging of Nectin-4 expression is therefore a potentially clinically relevant method for managing the application of Nectin-4-targeted therapies.
CONCLUSIONS: We show, as a proof of principle, that Nectin-4 expression can be detected on imaging and serves as an innovative biomarker for targeted therapy in urothelial cancer. Intra-individual heterogeneous expression of Nectin-4 in metastatic sites is frequent.