The toxicity of chlorophacinone and warfarin to house mice (Mus musculus).

Individually caged house mice (Mus m. musculus) were fed 0.025% warfarin (3(2-acetyl-1-phenylethyl)-4-hydroxycoumarin) or 0.025% chlorophacinone (2(1-(p-chlorophenyl)-1-phenyl) acetyl-1,3-indandione) for periods varying from 1 to 21 days. In all, 320 mice, 160 of each sex, were tested.A significant difference was found between the mortalities obtained by the two compounds. In feeding periods varying from 1-5 days chlorophacinone produced a mortality of 60-85% and warfarin only 5-75%. Five per cent, however, did survive 21 days feeding on each compound.A great variation in the susceptibility of individual mice was established for chlorophacinone as well as for warfarin.