Multiple sclerosis and related disorders · 2026
Increased PET 11C-PBR28 binding in multiple sclerosis normal-appearing white matter correlates with MRI measures of myelin loss.
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Vavasour Irene M, Vafai Nasim, Beauchemin Philippe, Shahinfard Elham, Laule Cornelia, Traboulsee Anthony, Sossi Vesna, Kolind Shannon H, Carruthers Robert L
Аннотация
INTRODUCTION: The Positron Emission Tomography (PET) tracer 11C-PBR28 binds to the Translocator Protein (TSPO), a marker of activated microglia. Advanced Magnetic Resonance (MR) techniques are sensitive to different tissue properties such as myelin (myelin water fraction, MWF; magnetisation transfer ratio, MTR; radial diffusivity, RD; choline, tCho), axons (axial diffusivity, AD; n-acetylaspartate, tNAA) and gliosis (myo-inositol, mI).
OBJECTIVE: To compare 11C-PBR28 binding across MS subtypes and investigate the correlation between 11C-PBR28 binding and advanced MR measures in normal-appearing white matter (NAWM) and lesions.
METHODS: Twelve people living with MS (7 relapsing-remitting MS (RRMS) and 5 progressive MS (PMS)) and 6 healthy controls (HC) were scanned with PET and MRI. A 70-minute 11C-PBR28 PET session was used to determine the non-displaceable binding potential (BPND). Advanced 3T MR included myelin water imaging, diffusion tensor imaging and spectroscopy. Mean measurements were extracted from lesion and NAWM masks.
RESULTS: Within NAWM, 11C-PBR28 binding was different between groups (BPND HC=0.70, RRMS=0.72, PMS=0.79; p = 0.03) and lesions exhibited lower BPND (NAWM=0.75, lesion=0.63; p = 0.0002). Lesions also had lower MWF (NAWM=0.13, lesion=0.08) and MTR (NAWM=41.5, lesion=33.5), and higher AD (NAWM=1.05, lesion=1.41) and RD (NAWM=0.50, lesion=0.83) than NAWM (all p < 0.0001). In NAWM, correlations were found between PBR-BPND and MWF (R=-0.71, p = 0.001) and MTR (R=-0.68, p = 0.003).
CONCLUSIONS: Increased inflammation and gliosis indicated by elevated 11C-PBR28 binding in NAWM are associated with demyelination (decreased MWF and MTR), especially in PMS. The ability to measure and monitor diffuse inflammation could help evaluate therapies designed to target whole brain immune activity and more specifically microglia.
OBJECTIVE: To compare 11C-PBR28 binding across MS subtypes and investigate the correlation between 11C-PBR28 binding and advanced MR measures in normal-appearing white matter (NAWM) and lesions.
METHODS: Twelve people living with MS (7 relapsing-remitting MS (RRMS) and 5 progressive MS (PMS)) and 6 healthy controls (HC) were scanned with PET and MRI. A 70-minute 11C-PBR28 PET session was used to determine the non-displaceable binding potential (BPND). Advanced 3T MR included myelin water imaging, diffusion tensor imaging and spectroscopy. Mean measurements were extracted from lesion and NAWM masks.
RESULTS: Within NAWM, 11C-PBR28 binding was different between groups (BPND HC=0.70, RRMS=0.72, PMS=0.79; p = 0.03) and lesions exhibited lower BPND (NAWM=0.75, lesion=0.63; p = 0.0002). Lesions also had lower MWF (NAWM=0.13, lesion=0.08) and MTR (NAWM=41.5, lesion=33.5), and higher AD (NAWM=1.05, lesion=1.41) and RD (NAWM=0.50, lesion=0.83) than NAWM (all p < 0.0001). In NAWM, correlations were found between PBR-BPND and MWF (R=-0.71, p = 0.001) and MTR (R=-0.68, p = 0.003).
CONCLUSIONS: Increased inflammation and gliosis indicated by elevated 11C-PBR28 binding in NAWM are associated with demyelination (decreased MWF and MTR), especially in PMS. The ability to measure and monitor diffuse inflammation could help evaluate therapies designed to target whole brain immune activity and more specifically microglia.