Severe anxiety, depression, and sleep disorders worsen prognosis in patients with septic shock.

Recent studies have revealed that patients with septic shock and acute skin failure (ASF) exhibit significantly higher levels of inflammatory cytokines, lactate, and C-reactive protein, along with elevated skin mottling score; modified early warning score (MEWS); and anxiety, depression, and Pittsburgh sleep quality index scores compared to those without ASF. Notably, these indicators are significantly correlated. Patients with septic shock accompanied by ASF tend to have a mean MEWS greater than 9, indicating severe disease progression. Therefore, it is essential to not only manage septic shock but also mitigate anxiety, depression, sleep disorders, and disturbances of consciousness. This article explores the impact of severe anxiety, depression, and sleep disorders on the prognosis of septic shock and discusses intervention strategies.