[Dnitrophenol--a dangerous doping agent].

BACKGROUND

Performance-enhancing drugs are frequently used by bodybuilders: anabolic steroids, growth hormone and insulin, only to mention a few. Many little known drugs are also used.

MATERIAL AND

METHODS

Two men aged 20 and 32 years, both active bodybuilders, complained about lassitude and malaise. Clinical and laboratory evaluation revealed an unusual cause of their complaints.

RESULTS

Laboratory investigation showed very low serum levels of free thyroxin and thyroid stimulating hormone (TSH), suggesting central depression of thyroid function. Both men then admitted taking dinitrophenol (approximately 5 mg/kg bodyweight/day) to "burn fat" before body-building competitions.

INTERPRETATION: Doctors should be aware that bodybuilders might use dinitrophenol. This toxic compound has severe metabolic effects. Overdose may cause hyperpyrexia and death. Use should be strongly discouraged.