The Association Between Serum Uric Acid to Creatinine Ratio and the Severity of Acute Pancreatitis.

OBJECTIVE

To examine the relationship between the serum uric acid to creatinine ratio (SUA/SCr) and the severity of acute pancreatitis.

METHODS

A total of 1612 patients diagnosed with acute pancreatitis at the Affiliated Hospital of Qingdao University were enrolled in this study. Patients were categorized into 2 groups: mild acute pancreatitis (MAP) and severe acute pancreatitis (SAP). Demographic data, including sex and age, along with biochemical indicators such as white blood cell count, arterial blood pH, glucose, triglycerides, and serum calcium, were collected and analyzed.

RESULTS

Among the 1612 patients, those with lower SUA/SCr levels were at an increased risk of developing severe acute pancreatitis ( P =0.026, OR=0.81, 95% CI: 0.72-0.98). Restricted cubic spline (RCS) analysis revealed a nonlinear, U-shaped relationship between SUA/SCr and the risk of severe acute pancreatitis. A clinical prediction model was developed, achieving an area under the curve (AUC) of 0.81.

CONCLUSION

Lower SUA/SCr levels are associated with an elevated risk of severe acute pancreatitis. These findings suggest that SUA/SCr may serve as a valuable biomarker for predicting the severity of acute pancreatitis in clinical practice.