[Electroencephalographically determined sedative effects (vigilosomnography) of the new Thienodiazepin-derivate clotiazepam (author's transl)].

In a double blind, randomized clinical study eighteen volunteers received either placebo or 5 mg diazepam or 5 mg clotiazepam at three different times at an interval of one week. Beside other parameters which have been measured a 60-minute polygraphic EEG recording was made thirty minutes after administration of the drugs. The vigilosomnograms revealed clear and reliable differences between placebo and the two active substances and suggest a sedative effect of both substances at the dose level used. There was only a slight difference between the two active substances. 5 mg clotiazepam produced a slightly stronger sedation than 5 mg diazepam. However, the records of autonomic side effects and subjective statements regarding the patients' condition showed that clotiazepam is associated with less side effects than diazepam.