Medicina oral, patologia oral y cirugia bucal · 2026
Identification of high-risk patients and metastatic progression in primary c/pN0 oral squamous cell carcinoma.
СтатьяНазвание и аннотация: Перевод в очереди
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Woodford Mark R, Andreou Avgi, Baba Masaya, van de Beek Irma, Di Malta Chiara, Glykofridis Iris, Grimes Hannah, Henske Elizabeth P, Iliopoulos Othon, Kurihara Masatoshi, Lazor Romain, Linehan W Marston, Matsumoto Kenki, Marciniak Stefan J, Namba Yukiko, Pause Arnim, Rajan Neil, Ray Anindita, Schmidt Laura S, Shi Wei, Steinlein Ortrud K, Thierauf Julia, Zoncu Roberto, Webb Anna, Mollapour Mehdi
Аннотация
BACKGROUND: Metastasis significantly decreases survival in oral cavity squamous cell carcinoma (OSCC). Even patients initially staged as cN0 may develop cervical or distant metastases during follow-up. Risk factors contributing to metastasis in this group are not fully understood.
MATERIALS AND METHODS: A retrospective cohort study was conducted on patients with primary cN0 OSCC treated between 2016 and 2020.
RESULTS: Of the 195 N0 OSCC patients included, 19 (9.7%) developed metastasis. Heavy alcohol use (HR 4.05, 95% CI:1.38-11.92, p=0.011) and depth of invasion (DOI) (HR 1.10, 95% CI:1.01-1.20, p=0.021) were significantly associated with the development of metastasis. Age, gender, site, neck procedure, radiotherapy, and T-class were not statistically significant predictors in this analysis.
CONCLUSIONS: Metastases occurred in nearly 10% of c/pN0 patients. Alcohol use and DOI were independent predictors, highlighting the need for individualized follow-up strategies and further research into alcohol-related OSCC.
MATERIALS AND METHODS: A retrospective cohort study was conducted on patients with primary cN0 OSCC treated between 2016 and 2020.
RESULTS: Of the 195 N0 OSCC patients included, 19 (9.7%) developed metastasis. Heavy alcohol use (HR 4.05, 95% CI:1.38-11.92, p=0.011) and depth of invasion (DOI) (HR 1.10, 95% CI:1.01-1.20, p=0.021) were significantly associated with the development of metastasis. Age, gender, site, neck procedure, radiotherapy, and T-class were not statistically significant predictors in this analysis.
CONCLUSIONS: Metastases occurred in nearly 10% of c/pN0 patients. Alcohol use and DOI were independent predictors, highlighting the need for individualized follow-up strategies and further research into alcohol-related OSCC.