Nature biomedical engineering · 2023
Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Murase Shuhei, Sakitani Naoyoshi, Maekawa Takahiro, Yoshino Daisuke, Takano Kouji, Konno Ayumu, Hirai Hirokazu, Saito Taku, Tanaka Sakae, Shinohara Keisuke, Kishi Takuya, Yoshikawa Yuki, Sakai Takamasa, Ayaori Makoto, Inanami Hirohiko, Tomiyasu Koji, Takashima Atsushi, Ogata Toru, Tsuchimochi Hirotsugu, Sato Shinya, Saito Shigeyoshi, Yoshino Kohzoh, Matsuura Yuiko, Funamoto Kenichi, Ochi Hiroki, Shinohara Masahiro, Nagao Motoshi, Sawada Yasuhiro
Аннотация
The mechanisms by which physical exercise benefits brain functions are not fully understood. Here, we show that vertically oscillating head motions mimicking mechanical accelerations experienced during fast walking, light jogging or treadmill running at a moderate velocity reduce the blood pressure of rats and human adults with hypertension. In hypertensive rats, shear stresses of less than 1 Pa resulting from interstitial-fluid flow induced by such passive head motions reduced the expression of the angiotensin II type-1 receptor in astrocytes in the rostral ventrolateral medulla, and the resulting antihypertensive effects were abrogated by hydrogel introduction that inhibited interstitial-fluid movement in the medulla. Our findings suggest that oscillatory mechanical interventions could be used to elicit antihypertensive effects.