Associated multiple congenital malformations in domestic animals. Contribution of four cases.

The incidence and significance of the appearance of various associated congenital malformations in a single individual have received poor attention in veterinary medicine. In this article, the malformations exhibited by four animals pertaining to three different animal species are described, and the possible reasons for the association of these anomalies are discussed from the viewpoint of the comparative medicine. All four animals showed two or three malformations constituting unrecognized teratological syndromes, so-called one-of-a-kind syndromes, which have not previously been described, at least in these particular animal species. A pig was affected by a series of craniofacial anomalies consisting in a first arch syndrome together with an occipito-parietal meningocele. Another member of the porcine species showed holoprosencephaly with cyclopia, various defects in the left forelimb and an extensive omphalocele. A dicephalic cat with cervical rachischisis and myeloschisis and a dog exhibiting spina bifida, curled tail and atresia ani are also described.