Epigenetic Role of Gastrointestinal Microbiota in Individuals Receiving Hemodialysis.

Burgeoning evidence suggests gastrointestinal (GI) microbiota regulate physiologic homeostasis in the human body and may influence adverse symptoms experienced by individuals receiving hemodialysis (HD). This study explores the epigenetic roles the GI microbiota play in this population. A cross-sectional descriptive correlational study was conducted. Survey data, stool, and blood specimens were collected from 20 patients at a local dialysis clinic. Statistically significant correlations were found between a subset of GI microbiota and miRNA that were different in groups with varying levels of fiber intake and physical activity, suggesting diet and exercise as potential modifiable factors to modulate the epigenetic role of GI microbiota. Findings may provide insights into additional therapeutic targets and allow nephrology nurses to play a critical role in optimizing individuals' lifestyle factors.