Fertility and sterility · 2009
Homologous in vitro fertilization in Turner syndrome: insights from a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Manno Massimo, Tomei Francesco, Cervi Marta, Gaspardo Gianfranco, Antonini-Canterin Francesco, Nicolosi Gianluigi
Аннотация
OBJECTIVE: To describe a bigeminal pregnancy obtained with a homologous intracytoplasmic sperm injection cycle in a patient with high-grade mosaic Turner syndrome (45,XO/47,XXX 97.5%/2.5%) with bicuspid aortic valve.
DESIGN: Case report.
SETTING: Unit of Pathophysiology of Human Reproduction in a general hospital.
PATIENT(S): Patient with mosaic Turner syndrome with bicuspid aortic valve.
INTERVENTION(S): Homologous intracytoplasmic sperm injection cycle after controlled ovarian hyperstimulation with a GnRH agonist flare-up depot protocol and menotropins.
MAIN OUTCOME MEASURE(S): Pregnancy development, echocardiographic monitoring of aortic root, karyotypes of progeny.
RESULT(S): Ongoing bigeminal pregnancy with the delivery of two healthy infants (46,XX and 46,XY, respectively) by cesarean section without any cardiovascular complication or aortic root echocardiographic modification in the mother.
CONCLUSION(S): Even in patients with Turner syndrome with high-grade 45,XO mosaicism and reduced ovarian reserve, a trial of homologous reproduction should be offered after a thorough cardiologic evaluation to avoid pregnancy-related cardiovascular complications.
DESIGN: Case report.
SETTING: Unit of Pathophysiology of Human Reproduction in a general hospital.
PATIENT(S): Patient with mosaic Turner syndrome with bicuspid aortic valve.
INTERVENTION(S): Homologous intracytoplasmic sperm injection cycle after controlled ovarian hyperstimulation with a GnRH agonist flare-up depot protocol and menotropins.
MAIN OUTCOME MEASURE(S): Pregnancy development, echocardiographic monitoring of aortic root, karyotypes of progeny.
RESULT(S): Ongoing bigeminal pregnancy with the delivery of two healthy infants (46,XX and 46,XY, respectively) by cesarean section without any cardiovascular complication or aortic root echocardiographic modification in the mother.
CONCLUSION(S): Even in patients with Turner syndrome with high-grade 45,XO mosaicism and reduced ovarian reserve, a trial of homologous reproduction should be offered after a thorough cardiologic evaluation to avoid pregnancy-related cardiovascular complications.