Homologous in vitro fertilization in Turner syndrome: insights from a case report.

OBJECTIVE

To describe a bigeminal pregnancy obtained with a homologous intracytoplasmic sperm injection cycle in a patient with high-grade mosaic Turner syndrome (45,XO/47,XXX 97.5%/2.5%) with bicuspid aortic valve.

DESIGN

Case report.

SETTING

Unit of Pathophysiology of Human Reproduction in a general hospital.

PATIENT(S): Patient with mosaic Turner syndrome with bicuspid aortic valve.

INTERVENTION(S): Homologous intracytoplasmic sperm injection cycle after controlled ovarian hyperstimulation with a GnRH agonist flare-up depot protocol and menotropins.

MAIN OUTCOME MEASURE(S): Pregnancy development, echocardiographic monitoring of aortic root, karyotypes of progeny.

RESULT(S): Ongoing bigeminal pregnancy with the delivery of two healthy infants (46,XX and 46,XY, respectively) by cesarean section without any cardiovascular complication or aortic root echocardiographic modification in the mother.

CONCLUSION(S): Even in patients with Turner syndrome with high-grade 45,XO mosaicism and reduced ovarian reserve, a trial of homologous reproduction should be offered after a thorough cardiologic evaluation to avoid pregnancy-related cardiovascular complications.