Synthesis of ferrocenyl/phenyl isothiazole-3-thione and isoselenazole-3-selenone as new heterocycles.

A direct one-pot synthesis for novel heterocycles, isothiazole-3-thiones and isoselenazole-3-selenones via the annulation of ferrocenyl/phenyl-β-chloro acrylaldehyde, amines and chalcogen powder (S and Se) has been established. The reaction was catalyzed by an environmentally benign iron cluster and Cu(OAc)2·H2O salt. The method is unique and rare as it consists of five consecutive bonds formation. Herein, all the 1,2 N, S isothiozole-3-thione and isoselenazole-3-selenone compounds are new and reported for the first time in this paper.