Veterinary anaesthesia and analgesia · 2010
Effects of ketamine-diazepam and ketamine-acepromazine combinations on intraocular pressure in rabbits.
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Ghaffari Masoud Selk, Moghaddassi Amir P
Аннотация
OBJECTIVE: To determine the effects of ketamine-diazepam and ketamine-acepromazine combinations on intraocular pressure (IOP) in rabbits.
STUDY DESIGN: Randomized clinical trial.
ANIMALS: Sixteen adult New Zealand white rabbits approximately one year old, weighing 2.3 +/- 0.2 kg were used in this study.
METHODS: The animals were randomly divided into two groups of eight each (KA and KD). The pre-treatment IOPs were recorded in both groups (T0). All rabbits in group KA received intramuscular ketamine-acepromazine (ketamine 30 mg kg(-1) + acepromazine 0.5 mg kg(-1)). Ketamine-diazepam (ketamine 30 mg kg(-1) + diazepam 1 mg kg(-1)) was administered intramuscularly in members of group KD. The IOP values were measured at 5 (T(5)), 15 (T(15)), and 20 (T(20)) minutes after drug administration in both treatment groups.
RESULTS: Significant increases in IOP values were observed in both treatment groups at T(5,) T(15), and T(20) in comparison to the baseline values. In group KA the mean +/- SD IOP at T(5,) T(15), and T(20) were 37 +/- 13 (p < 0.001), 35 +/- 4 (p < 0.001) and 34 +/- 4 mmHg (p < 0.001). The post-treatment mean +/- sd values in group KD were 23 +/- 8 (p = 0.002), 23 +/- 5 (p < 0.001) and 23 +/- 6 mmHg (p = 0.001) at 5, 15, and 20 minutes respectively.
CONCLUSION AND CLINICAL RELEVANCE: Both ketamine-diazepam and ketamine-acepromazine combinations increased IOP after intramuscular administration in rabbits.
STUDY DESIGN: Randomized clinical trial.
ANIMALS: Sixteen adult New Zealand white rabbits approximately one year old, weighing 2.3 +/- 0.2 kg were used in this study.
METHODS: The animals were randomly divided into two groups of eight each (KA and KD). The pre-treatment IOPs were recorded in both groups (T0). All rabbits in group KA received intramuscular ketamine-acepromazine (ketamine 30 mg kg(-1) + acepromazine 0.5 mg kg(-1)). Ketamine-diazepam (ketamine 30 mg kg(-1) + diazepam 1 mg kg(-1)) was administered intramuscularly in members of group KD. The IOP values were measured at 5 (T(5)), 15 (T(15)), and 20 (T(20)) minutes after drug administration in both treatment groups.
RESULTS: Significant increases in IOP values were observed in both treatment groups at T(5,) T(15), and T(20) in comparison to the baseline values. In group KA the mean +/- SD IOP at T(5,) T(15), and T(20) were 37 +/- 13 (p < 0.001), 35 +/- 4 (p < 0.001) and 34 +/- 4 mmHg (p < 0.001). The post-treatment mean +/- sd values in group KD were 23 +/- 8 (p = 0.002), 23 +/- 5 (p < 0.001) and 23 +/- 6 mmHg (p = 0.001) at 5, 15, and 20 minutes respectively.
CONCLUSION AND CLINICAL RELEVANCE: Both ketamine-diazepam and ketamine-acepromazine combinations increased IOP after intramuscular administration in rabbits.