Pharmacoepidemiology and drug safety · 2026
The Impact of Balance Solution on the Outcomes of Incident Peritoneal Dialysis Patients.
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Wang I-Kuan, Yu Tung-Min, Yen Tzung-Hai, Lin Cheng-Li, Tsai Fuu-Jen, Li Chi-Yuan, Lai Ping-Chin, Sung Fung-Chang
Аннотация
PURPOSE: This study investigates the impact of Balance solutions on the risks of technique failure, death, and the first episode of peritonitis in incident peritoneal dialysis (PD) patients.
METHODS: From the database of Taiwan's National Health Insurance, patients with newly diagnosed end-stage kidney disease receiving PD for at least 90 days and treated with Balance solutions at the initiation of PD from 2009 to 2020 were identified. For each Balance solution user, 10 patients using conventional PD solutions, matched by the index year, were randomly selected as the control cohort. Risks of technique failure, death and the first episode of peritonitis were compared between the two cohorts by the end of 2021.
RESULTS: Compared to the controls, the Balance solution users had an insignificant lower technique failure [156.3 vs. 172.0 per 1000 person-years; adjusted hazard ratio (HR) = 0.92, 95% confidence interval (CI) = 0.79-1.08] and mortality (203.5 vs. 223.7 per 1000 person-years; adjusted HR = 0.96, 95% CI = 0.83-1.09). The incident first episode of peritonitis was insignificant higher for the Balance solution cohort (139.9 vs. 117.1 per 1000 person-years), with an adjusted HR = 1.14 (95% CI = 0.94-1.37). However, the adjusted HR of the first peritonitis episode was 1.24 (95% CI = 1.02-1.49) using the time-dependent model.
CONCLUSIONS: The use of Balance solution is associated with similar risks of technique failure and mortality, but probably an increased risk of the first episode of peritonitis, compared with the use of conventional solutions among incident PD patients.
METHODS: From the database of Taiwan's National Health Insurance, patients with newly diagnosed end-stage kidney disease receiving PD for at least 90 days and treated with Balance solutions at the initiation of PD from 2009 to 2020 were identified. For each Balance solution user, 10 patients using conventional PD solutions, matched by the index year, were randomly selected as the control cohort. Risks of technique failure, death and the first episode of peritonitis were compared between the two cohorts by the end of 2021.
RESULTS: Compared to the controls, the Balance solution users had an insignificant lower technique failure [156.3 vs. 172.0 per 1000 person-years; adjusted hazard ratio (HR) = 0.92, 95% confidence interval (CI) = 0.79-1.08] and mortality (203.5 vs. 223.7 per 1000 person-years; adjusted HR = 0.96, 95% CI = 0.83-1.09). The incident first episode of peritonitis was insignificant higher for the Balance solution cohort (139.9 vs. 117.1 per 1000 person-years), with an adjusted HR = 1.14 (95% CI = 0.94-1.37). However, the adjusted HR of the first peritonitis episode was 1.24 (95% CI = 1.02-1.49) using the time-dependent model.
CONCLUSIONS: The use of Balance solution is associated with similar risks of technique failure and mortality, but probably an increased risk of the first episode of peritonitis, compared with the use of conventional solutions among incident PD patients.