La Revue de medecine interne · 2002
[Pregnancy-related hypertension].
Аннотация на английскомСтатьяОбзорНазвание и аннотация: Перевод в очереди
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Beaufils M
Аннотация
PURPOSE: Hypertension occurs in 10 to 15 p cent of pregnancies. Among them, 10 to 20% also have proteinuria. This situation defines preeclampsia, and involves a serious threat on fetal and even maternal prognosis. Presence of the hepatic (HELLP) syndrome still severely worsens the prognosis.
CURRENT KNOWLEDGE AND KEY POINTS: Pathophysiology of preeclampsia is based on a very early abnormality of placentation, leading to insufficient blood supply to the feto-placental unit. At the maternal level, the main consequence of placental ischemia is generalized endothelial dysfunction, responsible for systemic vasoconstriction and clotting abnormalities. In such a context, lowering blood pressure with drugs is quite inefficient, or even harmful. The prognosis of this disease is mainly related to the pertinence of obstetrical management.
FUTURE PROSPECTS AND PROJECTS: An early preventive strategy is the most logical approach of preeclampsia, its modalities remain under discussion.
CURRENT KNOWLEDGE AND KEY POINTS: Pathophysiology of preeclampsia is based on a very early abnormality of placentation, leading to insufficient blood supply to the feto-placental unit. At the maternal level, the main consequence of placental ischemia is generalized endothelial dysfunction, responsible for systemic vasoconstriction and clotting abnormalities. In such a context, lowering blood pressure with drugs is quite inefficient, or even harmful. The prognosis of this disease is mainly related to the pertinence of obstetrical management.
FUTURE PROSPECTS AND PROJECTS: An early preventive strategy is the most logical approach of preeclampsia, its modalities remain under discussion.