Journal of the American Pharmacists Association : JAPhA · 2025
Achievement of time in range goals among patients with diabetes using continuous glucose monitoring.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Azizi Faezeh, Diehl Katherine, Enser Lauren, Heacock Samantha
Аннотация
BACKGROUND: Despite robust evidence supporting continuous glucose monitoring (CGM) use, successful utilization remains relatively low.
OBJECTIVE(S): This study aimed to determine the percentage of patients with a baseline time in range (TIR) < 70% who achieved TIR ≥ 70% when using CGM and identify patient variables associated with either achievement or maintenance of the TIR goal within our institution.
METHODS: This was a retrospective, observational review of adult patients with diabetes using CGM for at least 6 months consecutively. Key exclusion criteria were gestational diabetes, pregnancy, nonadherence, and controlled baseline TIR. The primary outcome was the percentage of patients achieving TIR ≥ 70% within 6 months of starting CGM. Secondary outcomes included identifying patient variables associated with either achievement or maintenance of TIR goals and describing the relationship between TIR and hemoglobin A1c.
RESULTS: A total of 71 patients were included; 54% were male and the median age was 57 years (interquartile range [IQR] 39-75). Sixty-two percent of patients had type 2 diabetes (T2D). Fifty-four percent of patients achieved TIR ≥ 70% at any time during the study period, with a median time to achievement of 42 days (IQR 28-84). Among patients who achieved the TIR goal, 58% maintained this at 6 months and 67% also reached an A1c of < 7%. T2D, use of metformin, and glucagon-like peptide-1 receptor antagonists were positively associated with achievement of the TIR goal (P = 0.008, P = 0.026, and P = 0.004, respectively).
CONCLUSION: Among patients with diabetes using CGM consecutively for 6 months, most reached and maintained TIR goals. Larger studies are needed to confirm these findings.
OBJECTIVE(S): This study aimed to determine the percentage of patients with a baseline time in range (TIR) < 70% who achieved TIR ≥ 70% when using CGM and identify patient variables associated with either achievement or maintenance of the TIR goal within our institution.
METHODS: This was a retrospective, observational review of adult patients with diabetes using CGM for at least 6 months consecutively. Key exclusion criteria were gestational diabetes, pregnancy, nonadherence, and controlled baseline TIR. The primary outcome was the percentage of patients achieving TIR ≥ 70% within 6 months of starting CGM. Secondary outcomes included identifying patient variables associated with either achievement or maintenance of TIR goals and describing the relationship between TIR and hemoglobin A1c.
RESULTS: A total of 71 patients were included; 54% were male and the median age was 57 years (interquartile range [IQR] 39-75). Sixty-two percent of patients had type 2 diabetes (T2D). Fifty-four percent of patients achieved TIR ≥ 70% at any time during the study period, with a median time to achievement of 42 days (IQR 28-84). Among patients who achieved the TIR goal, 58% maintained this at 6 months and 67% also reached an A1c of < 7%. T2D, use of metformin, and glucagon-like peptide-1 receptor antagonists were positively associated with achievement of the TIR goal (P = 0.008, P = 0.026, and P = 0.004, respectively).
CONCLUSION: Among patients with diabetes using CGM consecutively for 6 months, most reached and maintained TIR goals. Larger studies are needed to confirm these findings.