Fertility and sterility · 2011
Androgens and poor responders: are we ready to take the plunge into clinical therapy?
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Fanchin Renato, Frydman Nelly, Even Marc, Berwanger da Silva Ana Luisa, Grynberg Michaël, Ayoubi Jean-Marc
Аннотация
OBJECTIVE: To review and summarize data from the scientific literature on the use of androgens to improve ovarian function.
DESIGN: Review of pertinent literature.
SETTING: University hospital.
PATIENT(S): Women exposed to androgens.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Critical review of the literature.
RESULT(S): The artificial increase of intra-ovarian androgen concentrations constitutes an attractive concept for improving the deficient ovarian function of poor responders. Data from studies conducted in animals treated with high-dose androgens, together with observations made in hyperandrogenic women or female-to-male transsexuals receiving virilizing androgen doses, indicate that androgens may increase follicle responsiveness to FSH and/or the number of growing follicles in the ovary. Yet, definite clinical demonstration of such a concept still is not available.
CONCLUSION(S): Current clinical approaches aiming at increasing androgen availability in the ovary showed conflicting results. Therefore, additional studies using proper strategies to achieving higher intra-ovarian androgen concentrations for longer intervals are required to define the clinical efficiency of androgens in poor responders.
DESIGN: Review of pertinent literature.
SETTING: University hospital.
PATIENT(S): Women exposed to androgens.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Critical review of the literature.
RESULT(S): The artificial increase of intra-ovarian androgen concentrations constitutes an attractive concept for improving the deficient ovarian function of poor responders. Data from studies conducted in animals treated with high-dose androgens, together with observations made in hyperandrogenic women or female-to-male transsexuals receiving virilizing androgen doses, indicate that androgens may increase follicle responsiveness to FSH and/or the number of growing follicles in the ovary. Yet, definite clinical demonstration of such a concept still is not available.
CONCLUSION(S): Current clinical approaches aiming at increasing androgen availability in the ovary showed conflicting results. Therefore, additional studies using proper strategies to achieving higher intra-ovarian androgen concentrations for longer intervals are required to define the clinical efficiency of androgens in poor responders.