[Determination of bisphenol A, nonylphenol, and octylphenol in PM_(2.5) by ultra-high performance liquid chromatography-tandem mass spectrometry].

OBJECTIVE

To establish a method for determination of bisphenol A, nonylphenol, and octylphenol in fine particulate matter(PM_(2.5)) by ultra-high performance liquid chromatography tandem mass spectrometry.

METHODS

PM_(2.5 )was collected by quartz fiber filter membrane(90 mm), 1/8 of which was extracted by methanol and purified by octadecyl silane bonded silica gel(C_(18)). The compounds were separated by Waters BEH C_(18) column(2.1 mm×100 mm, 1.7 μ m) under the mobile phase consisted of 0.1% ammonia and methanol, and then detected by multi reaction monitoring scanning mode with ESI negative scan, and quantified by internal standard method.

RESULTS

The correlation coefficients(r) of the three compounds were more than 0.999 in the range of 0.05-50 ng/mL. The detection limit and quantification limit of the method were 0.0007-0.001 ng/m~3 and 0.003-0.005 ng/m~3, respectively. The recoveries of blank sample spiked with 0.1, 1.0 and 10.0 ng/mL standard substance were 91.7%-120.2%, with relative standard deviation of 4.2%-12.3%(n=6).

CONCLUSION

The method established is high sensitivity, rapid, and accuracy, which can be used for the monitoring of bisphenol A, nonylphenol, and octylphenol in PM_(2.5).