Journal of the American Veterinary Medical Association · 2026
Use of a veterinary therapeutic renal diet in cats with early chronic kidney disease is associated with slower disease progression and improved survival.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Coyne Michael, Szlosek Donald, Webeck Jenna, Feliciano Rhaysa, Berger Noel, Doukas Jason, Denton David, Zhang Louisa Yu, Holt Natalee, Michael Helen, O'Kell Allison L, Riggott Julia, Sweet Sarah L, McCrann Donald J
Аннотация
OBJECTIVE: To determine disease progression and survival duration in cats diagnosed with early-stage chronic kidney disease (CKD) continuously treated with a veterinary therapeutic renal diet versus those untreated at diagnosis.
METHODS: This retrospective study utilized a commercial database of medical records from veterinary practices located in Canada and the US. Cats born between January 1, 2010, and December 31, 2014, diagnosed with early-stage CKD were randomly selected. Records were reviewed to determine the date of diagnosis and whether treatment with a therapeutic renal diet was initiated. Progression of CKD and survival duration were evaluated with longitudinal targeted maximum likelihood estimation modeling.
RESULTS: Of 1,430 cats with early CKD, 839 received a veterinary therapeutic renal diet and 591 did not. Dietary therapy was associated with reduced risk of progression. Treated CKD Stage 1 cats had a 45% lower hazard of progression (hazard ratio [HR], 0.55; 95% CI, 0.52 to 0.58). Treated CKD Stage 2 cats that had creatinine within and above the reference intervals had 46% (HR, 0.54; 95% CI, 0.50 to 0.58) and 41% (HR, 0.59; 95% CI, 0.56 to 0.62) lower hazards of progression, respectively. Cats treated with a therapeutic renal diet had a longer survival over 3 years: restricted mean survival time was 31.0 versus 26.0 months in untreated cats.
CONCLUSIONS: Use of a veterinary therapeutic renal diet in cats with early CKD slows disease progression and improves survival.
CLINICAL RELEVANCE: Early diagnosis and intervention with a therapeutic renal diet may optimize long-term outcomes in cats with CKD.
METHODS: This retrospective study utilized a commercial database of medical records from veterinary practices located in Canada and the US. Cats born between January 1, 2010, and December 31, 2014, diagnosed with early-stage CKD were randomly selected. Records were reviewed to determine the date of diagnosis and whether treatment with a therapeutic renal diet was initiated. Progression of CKD and survival duration were evaluated with longitudinal targeted maximum likelihood estimation modeling.
RESULTS: Of 1,430 cats with early CKD, 839 received a veterinary therapeutic renal diet and 591 did not. Dietary therapy was associated with reduced risk of progression. Treated CKD Stage 1 cats had a 45% lower hazard of progression (hazard ratio [HR], 0.55; 95% CI, 0.52 to 0.58). Treated CKD Stage 2 cats that had creatinine within and above the reference intervals had 46% (HR, 0.54; 95% CI, 0.50 to 0.58) and 41% (HR, 0.59; 95% CI, 0.56 to 0.62) lower hazards of progression, respectively. Cats treated with a therapeutic renal diet had a longer survival over 3 years: restricted mean survival time was 31.0 versus 26.0 months in untreated cats.
CONCLUSIONS: Use of a veterinary therapeutic renal diet in cats with early CKD slows disease progression and improves survival.
CLINICAL RELEVANCE: Early diagnosis and intervention with a therapeutic renal diet may optimize long-term outcomes in cats with CKD.