Медицинская библиотека · Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2003

Therapeutic effect of nimodipine on experimental brain injury.

Yang Shu-yuan, Wang Zeng-guang

Сравнительное исследованиеСтатьяПеревод в очереди

Аннотация

OBJECTIVE

To study the therapeutic effect of nimodipine on experimental brain injury.

METHODS

Experimental and control rabbits were subjected to a closed head injury. In one group nimodipine was given intravenously and the effect evaluated by electron microscopy, brain water content, calcium levels, transcranial Doppler, and intracranial pressure monitoring.

RESULTS

In rabbits treated with nimodipine the level of neuronal cytosolic free calcium was markedly decreased. There were less cellular damage and less spasm of the middle cerebral artery seen on electron microscopy. No difference regarding intracranial pressure changes between the two groups was noted.

CONCLUSIONS

Nimodipine has a protective action on brain injury by blocking a series of pathological reactions induced by neuronal calcium overload, and by reducing the spasm of brain vessels and improving cerebral blood flow.

Для цитирования: Yang Shu-yuan, Wang Zeng-guang. Therapeutic effect of nimodipine on experimental brain injury.. Chinese journal of traumatology = Zhonghua chuang shang za zhi. 2003.

Предметные рубрики MeSH

Animals Biopsy, Needle Brain Edema Brain Injuries Calcium Channel Blockers Disease Models, Animal Female Immunohistochemistry Infusions, Intravenous Male Nimodipine Probability Rabbits Reference Values Sensitivity and Specificity Statistics, Nonparametric

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