The Journal of clinical endocrinology and metabolism · 2015
Relating Phthalate and BPA Exposure to Metabolism in Peripubescence: The Role of Exposure Timing, Sex, and Puberty.
СтатьяПоддержка NIH: внешняя программаПоддержка правительства СШАНазвание и аннотация: Перевод в очереди
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Watkins Deborah J, Peterson Karen E, Ferguson Kelly K, Mercado-García Adriana, Tamayo y Ortiz Marcela, Cantoral Alejandra, Meeker John D, Téllez-Rojo Martha Maria
Аннотация
CONTEXT: Exposure to endocrine-disrupting chemicals during development may play a role in the increasing prevalence of metabolic syndrome and type 2 diabetes among children and adolescents by interfering with metabolic homeostasis.
OBJECTIVE: To explore associations between in utero and peripubertal urinary phthalate metabolite and bisphenol A (BPA) concentrations and markers of peripubertal metabolic homeostasis.
DESIGN: Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT): a longitudinal cohort study of pregnant women in Mexico City and their offspring.
SETTING: Public maternity hospitals in Mexico City.
PATIENTS OR OTHER PARTICIPANTS: Women recruited during pregnancy; offspring recruited for follow-up at age 8-14 years (n = 250).
INTERVENTIONS: None.
MAIN OUTCOME MEASURES: Fasting serum c-peptide, IGF-1, leptin, and glucose concentrations among children at follow-up; calculated measures of insulin secretion and insulin resistance.
RESULTS: Phthalate metabolites and BPA were associated with metabolism biomarkers at age 8-14 years in patterns that varied by sex, pubertal status, and exposure timing. For example, in utero monoethyl phthalate was associated with lower insulin secretion among pubertal boys (P = .02) and higher leptin among girls (P = .04). In utero di-2-ethylhexyl phthlate was associated with higher IGF-1 among pubertal girls; peripubertal di-2-ethylhexyl phthlate was associated with higher IGF-1, insulin secretion, and resistance among prepubertal girls. In contrast, peripubertal dibutyl phthalate, monobenzyl phthalate, and mono-3-carboxypropyl phthalate were associated with lower IGF-1 among pubertal boys. Peripubertal BPA was associated with higher leptin in boys (P = .01).
CONCLUSIONS: Considering the long-term health effects related to metabolic syndrome, additional research on exposure and metabolic outcomes across developmental periods and early adulthood is needed.
OBJECTIVE: To explore associations between in utero and peripubertal urinary phthalate metabolite and bisphenol A (BPA) concentrations and markers of peripubertal metabolic homeostasis.
DESIGN: Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT): a longitudinal cohort study of pregnant women in Mexico City and their offspring.
SETTING: Public maternity hospitals in Mexico City.
PATIENTS OR OTHER PARTICIPANTS: Women recruited during pregnancy; offspring recruited for follow-up at age 8-14 years (n = 250).
INTERVENTIONS: None.
MAIN OUTCOME MEASURES: Fasting serum c-peptide, IGF-1, leptin, and glucose concentrations among children at follow-up; calculated measures of insulin secretion and insulin resistance.
RESULTS: Phthalate metabolites and BPA were associated with metabolism biomarkers at age 8-14 years in patterns that varied by sex, pubertal status, and exposure timing. For example, in utero monoethyl phthalate was associated with lower insulin secretion among pubertal boys (P = .02) and higher leptin among girls (P = .04). In utero di-2-ethylhexyl phthlate was associated with higher IGF-1 among pubertal girls; peripubertal di-2-ethylhexyl phthlate was associated with higher IGF-1, insulin secretion, and resistance among prepubertal girls. In contrast, peripubertal dibutyl phthalate, monobenzyl phthalate, and mono-3-carboxypropyl phthalate were associated with lower IGF-1 among pubertal boys. Peripubertal BPA was associated with higher leptin in boys (P = .01).
CONCLUSIONS: Considering the long-term health effects related to metabolic syndrome, additional research on exposure and metabolic outcomes across developmental periods and early adulthood is needed.
Предметные рубрики MeSH
AdolescentAdultBenzhydryl CompoundsBiomarkersBlood GlucoseCohort StudiesDiethylhexyl PhthalateEndocrine DisruptorsEnergy MetabolismEnvironmental ExposureFemaleHomeostasisHumansInfant, NewbornInsulin ResistanceLeptinLongitudinal StudiesMaleMexicoMiddle AgedPhenolsPregnancyPubertySex FactorsYoung AdultBisphenol A Compounds