Assessing the impact of transcranial electrical stimulation on intracranial and cerebral perfusion pressures in patients with severe craniocerebral injury: A novel methodological approach.

BACKGROUND: Transcranial electrical stimulation (tES) protects brain cells and blood flow, making it an intriguing treatment option for skull and brain injury victims. Understanding how transcranial electroencephalography (tES) affects cerebral perfusion pressure (CPP) and intracranial pressure (ICP) might improve patient outcomes. Most techniques for evaluating ICP and CPP include intrusive procedures that might cause infections and hiccups. Additionally, current methods cannot optimize patient results by changing stimulation settings in real-time.

NEW METHOD: The Optimizing tES Parameters for Neuroprotection (O-tES-PN) approach addresses these issues. The system has many monitoring tools and an adaptive tES control mechanism. The O-tES-PN continually adjusts its dynamic stimulation settings based on intracranial and cerebral blood pressure. This keeps cerebral blood flow constant and reduces damage.

RESULTS: Our findings show that stable ICP and CPP enhance CBF modulation with the O-tES-PN design. The device may modify settings in real-time to give more concentrated and effective treatments with fewer adverse effects.

COMPARISON WITH EXISTING METHODS: Compared to invasive therapies, O-tES-PN is safer. It also improves therapy parameter control. Current technology allows continuous monitoring and stimulation level changes, which are limitations of previous systems.

CONCLUSIONS: The O-tES-PN treatment is less risky than other invasive treatments. Controlling the parameters of the treatment is also improved. The limitations of earlier systems are overcome by the current technology, which enables continuous monitoring and adjustments in stimulation level.