Cornea · 2024
Corneal Endothelial Cell Morphology in Eyes With Down Syndrome.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Okubo Hiroshi, Sotozono Chie, Kinoshita Shigeru
Аннотация
PURPOSE: To explore the morphological characteristics of corneal endothelial cells in eyes with Down syndrome.
METHODS: We conducted a comparative analysis of corneal endothelial cell density, coefficient of variation, hexagonal cell appearance rate, and corneal thickness using specular microscopy. Our study included 21 eyes of 11 patients with Down syndrome and 37 eyes of 19 control subjects.
RESULTS: In all eyes with Down syndrome, corneal endothelial cell density exceeded 2000 cells/mm 2 , and no abnormalities in cell morphology or significant differences from the control group were observed across all parameters.
CONCLUSIONS: The structure and function of corneal endothelial cells in eyes with Down syndrome were within the normal range, even in the presence of chromosomal abnormalities of 21-trisomy in somatic cells.
METHODS: We conducted a comparative analysis of corneal endothelial cell density, coefficient of variation, hexagonal cell appearance rate, and corneal thickness using specular microscopy. Our study included 21 eyes of 11 patients with Down syndrome and 37 eyes of 19 control subjects.
RESULTS: In all eyes with Down syndrome, corneal endothelial cell density exceeded 2000 cells/mm 2 , and no abnormalities in cell morphology or significant differences from the control group were observed across all parameters.
CONCLUSIONS: The structure and function of corneal endothelial cells in eyes with Down syndrome were within the normal range, even in the presence of chromosomal abnormalities of 21-trisomy in somatic cells.