Personalized medicine · 2024
The effect of RNLS gene polymorphisms on preeclampsia susceptibility: a meta-analysis study.
СтатьяМетаанализНазвание и аннотация: Перевод в очереди
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Salimi Saeedeh, Mohammadpour-Gharehbagh Abbas, Hedayat Mohaddeseh, Galavi Hamidreza, Harati-Sadegh Mahdiyeh
Аннотация
Aim: The authors designed a meta-analysis to find a comprehensive result of the impact of RNLS polymorphisms on preeclampsia (PE) susceptibility. Methods: The online databases PubMed, Scopus, and Google Scholar were employed for the purpose of literature search. Data analysis was conducted using STATA (ver. 12.0) and MetaGenyo web tool. Results: The findings showed that the RNLS rs10887800 polymorphism could increase risk of PE in allelic, codominant heterozygous and dominant genetic models. In addition, the analysis indicated that the RNLS rs2576178 polymorphism was associated with higher risk of PE in allelic, codominant homozygous, dominant, and recessive models. Conclusion: The findings of meta-analysis showed that the RNLS rs10887800 and rs2576178 polymorphisms could increase risk of PE in several genetic models.