A prospective randomized study comparing amoxycillin/clavulanate (augmentin) with cefuroxime-metronidazole as prophylaxis in gynaecological surgery.

Effective antibiotic prophylaxis is essential for preventing post-operative infections following gynecological surgery. This prospective randomized study conducted in a tertiary care hospital compared the efficacy of amoxicillin-clavulanate and cefuroxime-metronidazole as preoperative antibiotic regimens. Hence, two hundred women undergoing elective gynecological procedures were evenly divided into two groups: Group A received 1.2 g amoxicillin-clavulanate intravenously, while Group B received 1.5 g cefuroxime plus 500 mg metronidazole before surgical incision. Post-operative outcomes such as surgical site infection, febrile morbidity, urinary tract infections and duration of hospital stay were recorded and analyzed using SPSS, with significance set at p < 0.05. Thus, we show that both antibiotic combinations were equally effective in reducing post-operative infection rates and were well tolerated, supporting their safe use in gynecological surgery and the choice between regimens may depend on factors including hospital antibiotic policy, cost and local microbial resistance patterns.