Italian journal of pediatrics · 2021
Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate?
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Bahrami Reza, Ezzatabadi Aida, Mehdizadegan Nima, Mohammadi Hamid, Amoozgar Hamid, Edraki Mohammadreza
Аннотация
OBJECTIVES: The aim of this study was to collect consistent data on the efficacy and safety and evaluation hepatotoxicity of intravenous acetaminophen for the treatment of PDA in preterm infants.
METHODS: This is an observational longitudinal prospective study on 46 preterm infants with PDA who treated with high dose of acetaminophen and evaluated with echocardiography and serum liver enzymes at Hafez and Zeinabiyeh hospitals from January 2016 to December 2019.
RESULT: Forty-six preterm infants with PDA treated with intravenous acetaminophen. Rate of closure of PDA was 82.6. There was no significant difference after treatment regarding AST, ALT, Albumin, total and direct bilirubin (P value > 0.05) and no adverse side effects were observed in association with intravenous acetaminophen.
CONCLUSION: High dose of acetaminophen is not more effective than that with standard doses although without hepatotoxic side effect for PDA closure.
METHODS: This is an observational longitudinal prospective study on 46 preterm infants with PDA who treated with high dose of acetaminophen and evaluated with echocardiography and serum liver enzymes at Hafez and Zeinabiyeh hospitals from January 2016 to December 2019.
RESULT: Forty-six preterm infants with PDA treated with intravenous acetaminophen. Rate of closure of PDA was 82.6. There was no significant difference after treatment regarding AST, ALT, Albumin, total and direct bilirubin (P value > 0.05) and no adverse side effects were observed in association with intravenous acetaminophen.
CONCLUSION: High dose of acetaminophen is not more effective than that with standard doses although without hepatotoxic side effect for PDA closure.