Revista espanola de enfermedades digestivas · 2026
Prospective case series of non-tunnel, non-injection Z-POEM (NiZ-POEM) for Zenker's diverticulum ‒ Safety and short-term outcomes.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fraile-López Miguel, Ribes Carmen, Terán Álvaro, Moris María, López Arias María Jesús, Rodríguez Duque Juan Carlos, Cuadrado Lavín Antonio
Аннотация
BACKGROUND: Zenker per-oral endoscopic myotomy (Z-POEM) is increasingly used for the treatment of Zenker's diverticulum. This study aimed to evaluate the safety and short-term outcomes of the novel non-tunnel non-injection Z-POEM (NiZ-POEM) technique for Zenker's diverticulum.
METHODS: this single-center prospective study included patients with symptomatic Zenker's diverticulum who underwent NiZ-POEM between February 2023 and February 2025. The primary outcomes were technical and clinical success at six months. Secondary outcomes included quality-of-life improvement, adverse events rates, symptom recurrence and reintervention rates.
RESULTS: a total of 24 patients were included, with a median age of 77.5 years (54-98); 16 patients (66.7 %) were male. Four patients (16.7 %) had previously undergone treatment with subsequent symptom recurrence. The mean diverticulum size was 25 mm (± 11.5) and the median procedure time was 36.5 minutes (22-91). Technical success was achieved in all patients, and clinical success at six months was 100 % (95 % CI: 86.2-100 %). There was a significant improvement in dysphagia, with Dakkak-Bennett < 1 in all cases and median baseline Kothari-Haber Score System decreasing from 8 (2-11) to 0 (0-4) at six months post-procedure (p < 0.001). Quality of life improved significantly, with MD Anderson Dysphagia Inventory (MDADI) scores increasing from 53 (26-90) at baseline to 95 (71-100) at one month (median 41, IQR 32-49) and 99 (65-100) at six months (median 41, IQR 36-48). No adverse events occurred, and no symptom recurrence was observed during follow-up.
CONCLUSION: NiZ-POEM is a safe and effective technique for the treatment of Zenker's diverticulum. Its simplified approach may broaden the applicability of Z-POEM in clinical practice.
METHODS: this single-center prospective study included patients with symptomatic Zenker's diverticulum who underwent NiZ-POEM between February 2023 and February 2025. The primary outcomes were technical and clinical success at six months. Secondary outcomes included quality-of-life improvement, adverse events rates, symptom recurrence and reintervention rates.
RESULTS: a total of 24 patients were included, with a median age of 77.5 years (54-98); 16 patients (66.7 %) were male. Four patients (16.7 %) had previously undergone treatment with subsequent symptom recurrence. The mean diverticulum size was 25 mm (± 11.5) and the median procedure time was 36.5 minutes (22-91). Technical success was achieved in all patients, and clinical success at six months was 100 % (95 % CI: 86.2-100 %). There was a significant improvement in dysphagia, with Dakkak-Bennett < 1 in all cases and median baseline Kothari-Haber Score System decreasing from 8 (2-11) to 0 (0-4) at six months post-procedure (p < 0.001). Quality of life improved significantly, with MD Anderson Dysphagia Inventory (MDADI) scores increasing from 53 (26-90) at baseline to 95 (71-100) at one month (median 41, IQR 32-49) and 99 (65-100) at six months (median 41, IQR 36-48). No adverse events occurred, and no symptom recurrence was observed during follow-up.
CONCLUSION: NiZ-POEM is a safe and effective technique for the treatment of Zenker's diverticulum. Its simplified approach may broaden the applicability of Z-POEM in clinical practice.