Prognosis related to staging systems for chronic lymphocytic leukemia.

CONTEXT: Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disorder, characterized by B lymphocytic proliferation. CLL is the most frequent adult leukemia in Western countries, accounting for 25 to 30% of all white leukemic patients.

OBJECTIVE

To evaluate clinical and staging characteristics in prognosis of chronic lymphocytic leukemia.

DESIGN

Evaluation of clinical-staging data.

SETTING

Universidade Federal de São Paulo - Escola Paulista de Medicina / Universidade de Alfenas.

SAMPLE: 73 patients diagnosed from 1977 to 1994.

MAIN MEASUREMENTS: Sex, ethnic origin, age, lymphadenopathy, splenomegaly, hepatomegaly, three or more areas of lymphoid enlargement, hemoglobin (g/dl), lymphocytes/mm3, Platelets/mm3

RESULTS

Mean survival of patients was 76 months, median age was 65 years, ranging from 33 to 87. Forty-four patients (60.3%) were male and 29 (39.7%) female.

CONCLUSION

The Binet system determined a better prognosis than Rai.