ADMET & DMPK · 2026
Synthesis and characterization of bimetallic nanocomplex: Application for electrochemical determination of idarubicin as anti-cancer drug.
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Jassim Thekrayat Joodi, Barid Raheem Kubaish, Hamza Haider Dakhal
Аннотация
BACKGROUND AND PURPOSE: Cancer chemotherapy with antineoplastic drugs destroys cancer cells through complete cell death or stops cell development while protecting healthy cells from damage. Monitoring anticancer therapeutics in blood and tissues is important for determining their fate.
EXPERIMENTAL APPROACH: A novel binuclear complex with the formula [Cu(opd)2(H2O)(μ-SCN)Ni(opd)(SCN)3] (opd = o-phenylenediamine) was synthesized and characterized using Fourier transform infrared spectroscopy and UV-Vis spectroscopy. The solvothermal method was used to create a nanoscale version of the binuclear complex. X-ray powder diffraction, scanning electron microscopy, UV-Vis and FT-IR spectroscopy were used to characterize the nanocomplex. The solvothermal approach produced a nanocomplex with an average size of around 56 nm. The complex was tested for its antimicrobial properties on Gram-positive Staphylococcus aureus and Enterococcus faecalis, as well as Gram-negative Escherichia coli and Pseudomonas aeruginosa. Additionally, a screen-printed graphite electrode modified by a synthetic nanocomplex (Cu-Ni/SPGE) was presented as an improved electrochemical sensor for the detection of idarubicin (IRN).
KEY RESULTS: This sensor has a linear dynamic range from 0.01 to 3.0 μM and an impressive limit of detection of 0.003 μM under ideal testing circumstances.
CONCLUSION: The researchers used a Cu-Ni/SPGE system to perform electrochemical measurements on IRN. The Cu-Ni/SPGE outperformed the untreated SPGE in terms of IRN oxidation. The antibacterial activity of the complex was also studied.
EXPERIMENTAL APPROACH: A novel binuclear complex with the formula [Cu(opd)2(H2O)(μ-SCN)Ni(opd)(SCN)3] (opd = o-phenylenediamine) was synthesized and characterized using Fourier transform infrared spectroscopy and UV-Vis spectroscopy. The solvothermal method was used to create a nanoscale version of the binuclear complex. X-ray powder diffraction, scanning electron microscopy, UV-Vis and FT-IR spectroscopy were used to characterize the nanocomplex. The solvothermal approach produced a nanocomplex with an average size of around 56 nm. The complex was tested for its antimicrobial properties on Gram-positive Staphylococcus aureus and Enterococcus faecalis, as well as Gram-negative Escherichia coli and Pseudomonas aeruginosa. Additionally, a screen-printed graphite electrode modified by a synthetic nanocomplex (Cu-Ni/SPGE) was presented as an improved electrochemical sensor for the detection of idarubicin (IRN).
KEY RESULTS: This sensor has a linear dynamic range from 0.01 to 3.0 μM and an impressive limit of detection of 0.003 μM under ideal testing circumstances.
CONCLUSION: The researchers used a Cu-Ni/SPGE system to perform electrochemical measurements on IRN. The Cu-Ni/SPGE outperformed the untreated SPGE in terms of IRN oxidation. The antibacterial activity of the complex was also studied.